Reference

Biohacking
Glossary

Quick-reference definitions for the compounds, peptides, and supplements used in performance and longevity protocols.

BPC-157

Body Protection Compound 157 · Peptide

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BPC-157 is a synthetic peptide derived from a stomach protein. It accelerates healing of tendons, ligaments, muscles, and gut lining. Extensively studied in animal models with robust anecdotal human evidence.

Dose
200–500mcg/day
Cycle
4–6 weeks on, 2 weeks off

GHK-Cu

Copper Peptide GHK-Cu · Peptide

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GHK-Cu stimulates collagen synthesis, wound healing, and stem cell activation. Has strong anti-inflammatory properties and has been shown to reverse aging-associated gene expression patterns.

Dose
1–2mg/day
Cycle
4–6 weeks on, 4 weeks off. Topical: indefinite.

Ipamorelin

Ipamorelin Acetate · Peptide

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Ipamorelin is a selective GH secretagogue that triggers natural growth hormone pulses. Unlike other GH peptides, it doesn't elevate cortisol or prolactin. Improves sleep, recovery, and body composition.

Dose
200–300mcg before bed
Cycle
3–6 months, 5 days on 2 off

Melanotan I

Afamelanotide · Peptide

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Melanotan I (afamelanotide) is a non-selective melanocortin receptor agonist. FDA-approved as Scenesse for erythropoietic protoporphyria. Provides deep tanning without UV exposure. Longer half-life and cleaner profile than MT-II.

Dose
0.5–2mg every 3–4 days (loading), 1mg/week (maintenance)
Cycle
2–3 weeks loading, then maintenance as needed

Melanotan II

Melanotan II (MT-II) · Peptide

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MT-II activates melanocortin 1/3/4/5 receptors producing stronger tanning than MT-I, significant appetite suppression via MC4R, libido enhancement, and some thermogenic fat loss. More potent but shorter acting than Melanotan I.

Dose
0.25–1mg/day (loading), 0.5mg 2–3x/week (maintenance)
Cycle
8 weeks on, 4 weeks off

NMN

Nicotinamide Mononucleotide · Longevity

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NMN is a direct precursor to NAD+, the molecule central to energy metabolism and DNA repair. NAD+ declines with age — supplementation supports cellular energy, mitochondrial function, and longevity pathways.

Dose
250–1000mg/day AM fasted
Cycle
Ongoing — no cycling required

Retatrutide

Retatrutide (RETA) · Metabolic Peptide

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Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors — a triple mechanism that produced up to 24% body weight reduction in Phase 2 trials, exceeding semaglutide. Phase 3 trials ongoing.

Dose
0.5mg/week titrating to 4–12mg/week
Cycle
Minimum 6-month commitment. Slow titration essential.

Semax

Synthetic ACTH/MSH Fragment · Nootropic Peptide

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Semax is a synthetic peptide based on ACTH that dramatically increases BDNF (Brain-Derived Neurotrophic Factor). Enhances memory, focus, and processing speed. Neuroprotective. Prescription drug in Russia and Ukraine.

Dose
200–900mcg/day via nasal spray
Cycle
2 weeks on, 1 week off

TB-500

Thymosin Beta-4 · Peptide

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TB-500 promotes whole-body healing by upregulating actin, the protein that builds cell structure. Reduces inflammation, scar tissue, and improves range of motion. Synergistic with BPC-157.

Dose
2–2.5mg, 2x/week (loading), 1x/week (maintenance)
Cycle
4–6 weeks loading, then maintenance

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